Heart failure etiology affects peripheral vascular endothelial function after cardiac transplantation
Ayan R. Patel, MD*,
Jeffrey T. Kuvin, MD*,
Natesa G. Pandian, MD, FACC*,
John J. Smith, MD, PhD, FACC*  ,
James E. Udelson, MD, FACC* ,
Michael E. Mendelsohn, MD, FACC,
Marvin A. Konstam, MD, FACC* and
Richard H. Karas, MD, PhD, FACC
* Cardiovascular Imaging and Hemodynamic Laboratory, New England Medical Center Hospitals Inc., Tufts University School of Medicine, Boston, Massachusetts, USA
Molecular Cardiology Research Institute, Division of Cardiology, Department of Medicine, New England Medical Center Hospitals Inc., Tufts University School of Medicine, Boston, Massachusetts, USA
View larger version (28K):
[in a new window]
|
Figure 1 Endothelium-dependent vasodilation. The percent change in brachial artery diameter during reactive hyperemia in heart failure patients (open bars) and transplant recipients (closed bars) compared with normal controls (hatched bars) is shown. Compared with controls, flow-mediated dilation (FMD) was significantly decreased in heart failure patients with either ischemic cardiomyopathy or nonischemic cardiomyopathy. Flow-mediated dilation was also impaired in transplant recipients with a history of ischemic cardiomyopathy. In contrast, FMD in transplant recipients with a history of nonischemic cardiomyopathy was significantly higher than that of heart failure patients with nonischemic cardiomyopathy or transplant recipients with a history of ischemic heart disease. *p < 0.05 compared with normal control.
|
|
View larger version (31K):
[in a new window]
|
Figure 2 Endothelium-independent vasodilation. The percent change in brachial artery diameter after administration of nitroglycerin in heart failure patients (open bars) and transplant recipients (closed bars) compared with normal controls (hatched bars) is shown. There were no significant differences between groups.
|
|
|
