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Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans

Roland E. Schmieder, MD, FACC^*, Jeanette Erdmann, PhD, Christian Delles, MD^*, Johannes Jacobi, MD^*, Eckart Fleck, MD, Karl Hilgers, MD^* and Vera Regitz-Zagrosek, MD

^* Department of Medicine IV/Nephrology, University of Erlangen-Nürnberg, Nürnberg, Germany
Department of Internal Medicine and Cardiology, Charité, Campus Virchow-Klinikum, Humboldt University and Deutsches Herzzentrum Berlin, Berlin, Germany

View larger version (148K): [in a new window]   Figure 1 (a) Part of the nucleotide sequence of the human angiotensin II type 2-receptor gene. The position of the G>A substitution at position +1675 is marked with an arrow. First row: DNA-sequence of a patient carrying the G-allele. Second row: DNA-sequence of a patient carrying both alleles (G/A). Third row: DNA-sequence of a patient carrying the A-allele. (b) Representative example of a SSCP-gel showing the characteristic band-pattern of the +1675 G/A polymorphism after denaturing and loading on a 10% PAA gel at 4°C. Lane 1: PCR-product of a heterozygote patient designated G/A. Lane 2: PCR-product of a patient carrying the G-allele (G). Lane 3: PCR-product of a patient carrying the A-allele (A). Lane 4 and 5: PCR-products of patients carrying the G-allele.

View larger version (10K): [in a new window]   Figure 2 Left ventricular mass in normotensive and hypertensive subjects classified according to the X-chromosomal located +1675 G/A polymorphism of the angiotensin II AT2-receptor gene. Solid circle= A-allele; solid square= G-allele. Data are given by means (symbols) ± 95% confidence interval.

View larger version (13K): [in a new window]   Figure 3 Posterior, septal and relative wall thickness in normotensive and hypertensive subjects classified according to the X-chromosomal located +1675 G/A polymorphism of the AT2-receptor gene. Solid circle= A-allele; solid square = G-allele. Data are given by means (symbols) ± 95% confidence interval.