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The physiological role of endogenous endothelin in the regulation of human coronary vasomotor tone

Philip A. MacCarthy, BSc, PhD, MRCP^*, Nicholas C. Pegge, MA, MBBS, MRCP^*, Bernard D. Prendergast, MD, BMedSci, MRCP^*, Ajay M. Shah, MD, FRCP, FESC and Peter H. Groves, MBBS, MD, FRCP^*

^* Department of Cardiology, University Hospital of Wales, Heath Park, Cardiff, United Kingdom
GKT School of Medicine, King’s College London, Bessemer Road, London, United Kingdom

View larger version (20K): [in a new window]   Figure 1 Schematic representation of experimental protocol. B = baseline measurements; A = angiogram; F = Doppler flow-wire measurement; H = hemodynamic measurements, including blood pressure, heart rate, and ECG.

View larger version (31K): [in a new window]   Figure 2 Mean cross-sectional artery area at baseline, at the end of the 15-min BQ123 infusion (peak BQ123) and 15-min post-BQ123 infusion, in the proximal, mid and distal study vessel. Lower panels show percentage change from baseline. *p < 0.05; **p < 0.001 vs. baseline.

View larger version (20K): [in a new window]   Figure 3 Mean values for study vessel blood flow at baseline, at the end of the 15-min BQ123 infusion (peak BQ123) and 15-min post-BQ123 infusion. Lower panel shows percentage change from baseline. *p < 0.001 vs. baseline.