This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Garot, J.e. Articles by Lima, J. A. C. Search for Related Content PubMed PubMed Citation Articles by Garot, J.e. Articles by Lima, J. A. C.

Transmural contractile reserve after reperfused myocardial infarction in dogs

J.érôme Garot, MD^*, David A. Bluemke, MD, PhD, Nael F. Osman, PhD, Carlos E. Rochitte, MD^*, Elias A. Zerhouni, MD, Jerry L. Prince, PhD and João A. C. Lima, MD, FACC^*

^* Cardiology Division of the Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Department of Radiology of the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Department of Electrical and Computer Engineering of the Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA

View larger version (27K): [in a new window]   Figure 1 Tagged images of the left ventricular short-axis view (A), the magnitudes of the corresponding Fourier transform (B) and the corresponding phase images (C) in a dog with anterior infarct. The circles in the Fourier domain correspond to the size of the bandpass filter. Myocardial strain is directly related to the derivative of the phase, that is, the slope of the phase pattern (D). (E) Shows the left ventricular map of circumferential strain obtained by harmonic phase imaging in the same animal. Black indicates shortening, whereas yellow indicates stretching.

View larger version (31K): [in a new window]   Figure 2 Circumferential shortening (Ecc) (A), maximal shortening (E2) (B), E2 direction (C), radial thickening (Err) (D) and maximal elongation (E1) (E) are shown in remote, risk and infarcted myocardium at rest and 5 µg·kg–1·min–1 dobutamine. Infarcted = combination of segments with infarct extension of wall thickness. *p < 0.01 versus rest.

View larger version (14K): [in a new window]   Figure 3 Transmural contractile reserve as assessed for circumferential shortening (Ecc) and maximal shortening (E2). (A) Radial thickening (Err) and maximal elongation (E1). (B) In segments with subendocardial () and transmural extent (> of wall thickness) of infarct. open squares = rest; closed squares = dobutamine; black line = subendocardium; large dotted line = midwall; small dotted line = subepicardium. *p < 0.01 versus rest.

View larger version (59K): [in a new window]   Figure 4 Histopathologic specimens of the left ventricular myocardium (upper panel) in dogs with transmural (left) and subendocardial (right) reperfused anterior infarct. The corresponding short-axis tagged images of the left ventricle at end-systole, at rest and 5 µg·kg–1·min–1 dobutamine are shown in midpanel. Regional myocardial strain maps (circumferential shortening) by harmonic phase imaging are displayed in the lower panel. Black indicates shortening and yellow indicates stretching. MI = myocardial infarction.