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Effect of mitral valve surgery on exercise capacity, ventricular ejection fraction and neurohormonal activation in patients with severe mitral regurgitation

Thierry Le Tourneau, MD^*, Pascal de Groote, MD, Alain Millaire, MD, PhD, Claude Foucher, MD, Christine Savoye, MD^*, Pascal Pigny, PhD, PharmD, Alain Prat, MD^||, Henri Warembourg, MD^|| and Jean Marc Lablanche, MD

^* Department of Cardiovascular Exploration, Hospital of Cardiology, Lille, France
Department of Cardiology C, Hospital of Cardiology, Lille, France
Department of Nuclear Medicine, Hospital Roger Salengro, Lille, France
Laboratory of Endocrinology, U.S.N.A., Lille, France
^|| Department of Cardiovascular Surgery, Hospital of Cardiology, Regional Hospital and University Center, Lille, France

View larger version (36K): [in a new window]   Figure 1 Changes in LV and RV ejection fraction according to the type of corrective surgery performed. LV = left ventricle; RV = right ventricle.

View larger version (39K): [in a new window]   Figure 2 Analysis of regional ejection fraction of the left ventricle: there is a significant decrease in regional ejection fraction after mitral valve replacement in the regions 4 and 5 (apicolateral area) compared with mitral valve repair (p < 0.05).