Adhesion molecules in nonrheumatic aortic valve disease: endothelial expression, serum levels and effects of valve replacement
Nitin K. Ghaisas, MD, MRCPI*,
J. Brendan Foley, MD, MRCP*,
D. Sean O’Briain, MRCPath ,
Peter Crean, FRCPI*,
Dermot Kelleher, MD, MRCPI and
Michael Walsh, MD, FRCPI, FACC*
* Department of Cardiology, St. James’s Hospital, Dublin, Ireland
Department of Pathology, St. James’s Hospital, Dublin, Ireland
Department of Clinical Medicine, St. James’s Hospital, Dublin, Ireland
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Figure 1 Surgically removed bicuspid stenotic aortic valve (A) staining positive for CD34 demonstrating endothelium, and also staining for (B) E-selectin; (C) negative control for this valve. Original magnification x 50. Scale bar 20 µm.
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Figure 2 Positive staining for (A) ICAM-1 in a bicuspid stenotic aortic valve, and for (B) VCAM-1 and (C) E-selectin in a patient with aortic stenosis of a tricuspid valve. Original magnification x 50. Scale bar 20 µm.
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Figure 3 Section of tricuspid aortic valve from a patient with aortic stenosis showing (A) positive staining for CD34 while (B) demonstrates negative staining for ICAM-1 and (C) demonstrates weak staining for E-selectin in the same patient. Original magnification x 50. Scale bar 20 µm.
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Figure 4 Dotplots of the data for soluble adhesion molecule levels overlaid with boxplots showing medians, 25th and 75th percentiles with values, range (whiskers) and extreme values (circles for outliers, stars for extreme outliers). (A) soluble E-selectin (sE-selectin), (B) soluble ICAM-1 (sICAM-1) and (C) soluble VCAM-1 (sVCAM-1).
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