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Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: an effect prevented by vitamins C and E

Lawrence M. Title, MD^*, Peter M. Cummings, BA, MSc, Karen Giddens^* and Bassam A. Nassar, MB, PhD, BCh

^* Division of Cardiology, Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada
Department of Pathology and Laboratory Medicine at the Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada

View larger version (17K): [in a new window]   Figure 1 Effects of oral glucose loading alone, (solid circle), or with vitamins C and E, (open circle) on flow-mediated dilatation (FMD; mean ± SE) over 4 h. Vitamins C and E prevented the acute attenuation of FMD seen with glucose loading alone (p = 0.0003 by two-way analysis of variance for response of glucose alone versus glucose with vitamins). *p < 0.05 compared with FMD at baseline (0 h); p < 0.05 compared with glucose with vitamins at 2 h.

View larger version (18K): [in a new window]   Figure 2 Mean change in flow-mediated dilatation (FMD) at 2 h postprandial compared with preprandial FMD for glucose loading alone (solid bar) versus glucose loading plus vitamins (open bar). The bars represent mean ± standard error. *p = 0.001 for glucose alone versus glucose with vitamins.