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Antiremodeling effects on the left ventricle during beta-blockade with metoprolol in the treatment of chronic heart failure

Bjoern A. Groenning, MD^* , Jens C. Nilsson, MD^*, Lars Sondergaard, MD^* , Thomas Fritz-Hansen, MD^*, Henrik B. W. Larsson, MD, DMSc^* and Per R. Hildebrandt, MD, DMSc

^* Danish Research Center of Magnetic Resonance, Department of Magnetic Resonance, H:S Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark
Department of Cardiology and Endocrinology, H:S Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark

View larger version (12K): [in a new window]   Figure 1 LVEDVI over time. Mean LVEDVI is shown in the metoprolol CR/XL group and in the placebo group at baseline, five or seven weeks and six months after randomization. *The metoprolol CR/XL group versus the placebo group. CI = confidence interval; LVEDVI = left ventricular end-diastolic volume index.

View larger version (12K): [in a new window]   Figure 2 LVESVI over time. Mean LVESVI is shown in the metoprolol CR/XL group and in the placebo group at baseline, five or seven weeks and six months after randomization. *The metoprolol CR/XL group versus the placebo group. CI = confidence interval; LVESVI = left ventricular end-systolic volume index.

View larger version (12K): [in a new window]   Figure 3 LVEF over time. Mean LVEF is shown in the metoprolol CR/XL group and in the placebo group at baseline, 5 or 7 weeks and six months after randomization. *The metoprolol CR/XL group versus the placebo group. CI = confidence interval; LVEF = left ventricular ejection fraction.

View larger version (12K): [in a new window]   Figure 4 LVmassI over time. Mean LVmassI is shown in the metoprolol CR/XL group and in the placebo group at baseline, five or seven weeks and six months after randomization. *The metoprolol CR/XL group versus the placebo group. Metoprolol CR/XL group versus baseline: p = 0.01; placebo group versus baseline: p = 0.005. CI = confidence interval; LVmassI = left ventricular mass index.