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Thrombin formation and fibrinolytic activity in patients with acute myocardial infarction or unstable angina: in-hospital course and relationship with recurrent angina at rest

^a Unitat Coronària, Servei de Cardiologia, Hospital General Vall d’Hebron, Barcelona, Spain
^b Unitat de Recerca d’Hemostàsia, Hospital General Vall d’Hebron, Barcelona, Spain

View larger version (33K): [in a new window]   Figure 1 Thrombin-antithrombin complex (upper panel) and fibrinogen plasma levels (lower panel) (mean ± SEM) on days 1 and 10 and at 3 months in patients with unstable angina or acute myocardial infarction with (dashed bars) or without in-hospital angina (open bars). Also shown are values from a control group. Thrombin-antithrombin complex values at the three stages were higher in patients than they were in the control group (see text). There were significant (*) intragroup differences (ANOVA) in the two subsets as well as a trend towards intergroup differences (ANOVA, p < 0.077), mainly because of the higher values at 10 days in patients with in-hospital angina than in those without (p < 0.013). Fibrinogen levels were also higher in patients than they were in the control group and increased significantly at 10 days to a comparable extent in patients with or without in-hospital angina. Intragroup differences (ANOVA) were significant (*). ANOVA = analysis of variance.

View larger version (31K): [in a new window]   Figure 2 D-dimer (upper panel) and PAI-1 plasma levels (lower panel) (mean ± SEM) on days 1 and 10 and at 3 months in patients with unstable angina or acute myocardial infarction with (dashed bars) or without in-hospital angina (open bars) and in those from a control group. D-dimer values at the three stages were higher in patients than they were in the control group (see text). There were significant intragroup differences (*) (ANOVA) in the two subsets as well as intergroup differences (ANOVA, p < 0.029). At 10 days values were significantly higher in patients with in-hospital angina than they were in those without (p < 0.004). Plasminogen activator inhibitor, type 1 levels were also higher in patients than they were in the control group, and there were significant (*) intragroup (ANOVA) as well as intergroup differences (ANOVA, p < 0.029). The latter were mainly related to the particularly higher PAI-1 levels on day one in patients who developed in-hospital angina than in those who did not (p < 0.008). ANOVA = analysis of variance; PAI-1 = plasminogen activator inhibitor, type 1.