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Immunoglobulin treatment ameliorates murine myocarditis associated with reduction of neurohumoral activity and improvement of extracellular matrix change

Chiharu Kishimoto, MD, PhD^*, Nami Takamatsu, RN^*, Hiroshi Kawamata, MD, Hiromichi Shinohara, MD, PhD and Hiroshi Ochiai, MD, PhD

^* Second Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
Department of Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
Department of Human Science, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan

View larger version (76K): [in a new window]   Figure 1 Photominographs showing representative abnormalities of fibrin deposition and myocardial fibrosis in heart of a mouse with myocarditis in Experiment I (day 14). Interstitial fibrin deposition (A, arrows) and fibrosis (B, blue) in areas of myocardial necrosis in untreated group was more severe than in immunoglobulin-treated group (C, D). A, C = Immunoperoxidase stain for fibrin; B, D = Masson’s trichrome stain for fibrosis: A, B, C, D x120.