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Local delivery of 17-beta-estradiol decreases neointimal hyperplasia after coronary angioplasty in a porcine model

^a Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada

View larger version (32K): [in a new window]   Figure 1 Representative light micrographs (x40) of arterial segments from the three treatment groups: (A) BE-treated artery (extent of injury = 0.23, neointimal area = 0.24 mm2); (B) PTCA only–treated artery (extent of injury = 0.29, neointimal area = 1.00 mm2); and (C) vehicle only–treated artery (extent of injury = 0.23, neointimal area = 1.3 mm2).

View larger version (23K): [in a new window]   Figure 2 Comparison of (A) neointimal area (NI); (B) neointimal/media area (NI/M); (C) restenotic index; and (D) neointimal area/fracture length (NI/F) between PTCA-only and BE-treated groups, and between PTCA only and vehicle-only groups. *p = NS. **p < 0.05.