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Magnetic resonance spectroscopy evidence of abnormal cardiac energetics in Xp21 muscular dystrophy

Jenifer G. Crilley, MB, ChB, MRCP^* , Ernest A. Boehm, DPhil, Bheeshma Rajagopalan, MB, DPhil, ChB, FRCP^*, Andrew M. Blamire, PhD^*, Peter Styles, DPhil^*, Francesco Muntoni, MD, FRCPCH, David Hilton-Jones, MD, FRCP and Kieran Clarke, PhD

^* Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Oxford, United Kingdom
BHF Molecular Cardiology Group, Department of Biochemistry, University of Oxford, South Parks Road, Oxford,United Kingdom
Department of Pediatrics and Neonatal Medicine, Imperial College of Medicine, Hammersmith Campus, London, United Kingdom
Muscle and Nerve Centre, Radcliffe Infirmary, Oxford, United Kingdom

View larger version (21K): [in a new window]   Figure 1 Examples of spectra from a patient with BMD, a female carrier of muscular dystrophy (MD) and a healthy volunteer.

View larger version (12K): [in a new window]   Figure 2 Results of saturation-corrected PCr/ATP for patients with BMD and carriers of muscular dystrophy (MD) as compared with control subjects. * and **p < 0.0001.