Increased activity of endogenous endothelin in patients with hypercholesterolemia
Carmine Cardillo, MDa,
Crescence M. Kilcoyne, RN, MSa,
Richard O. Cannon, III, MD, FACCa and
Julio A. Panza, MD, FACCa
a Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
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Figure 1 Graph showing FBF responses to intra-arterial infusion of BQ-123 (100 nmol/min) in normal subjects and hypercholesterolemic patients. Values represent mean ± SEM. The p value refers to the comparison between the two groups in forearm blood flow changes from baseline during selective ETA blockade by analysis of variance. There was no significant interaction between diagnosis (normal or hypercholesterolemic) and time of infusion.
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Figure 2 Graph showing FBF responses to endothelin-1 (5 pmol/min) in control subjects and hypercholesterolemic patients. Values represent mean ± SEM. The p value refers to the difference between the two groups in FBF response to endothelin-1 infusion by analysis of variance.
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Figure 3 Graph showing FBF responses to intra-arterial infusion of BQ-123 (100 nmol/min) for 2 h (open circles) and to BQ-123 alone for 1 h followed by the combination with BQ-788 (50 nmol/min) for another hour (closed circles) in six hypercholesterolemic patients. Values represent mean ± SEM. The p value refers to the comparison in FBF changes during selective ETA blockade between the two different occasions (left) and during nonselective ETA/ETB blockade vs. selective ETA blockade (right) by analysis of variance. In the latter comparison, there was no significant interaction between treatment (BQ-123 alone vs. combination of BQ-123 and BQ-788) and time of infusion.
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