This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ellis, G. R. Articles by Frenneaux, M. P. Search for Related Content PubMed PubMed Citation Articles by Ellis, G. R. Articles by Frenneaux, M. P.

Neutrophil superoxide anion–generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy

Gethin R. Ellis, MRCP^a, Richard A. Anderson, MRCP^a, Derek Lang, PhD^a, Daniel J. Blackman, MRCP^a, R. H. Keith Morris, MSc, Jayne Morris-Thurgood, PhD^a, Ian F. W. McDowell, MD^a, Simon K. Jackson, PhD^a, Malcolm J. Lewis, MB, DSc^a and Michael P. Frenneaux, MD, FRCP, FACC^a

^a Cardiovascular Sciences Research Group, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, Wales, United Kingdom
School of Biomedical Sciences, University of Wales Institute of Cardiff, Cardiff, Wales, United Kingdom

View larger version (10K): [in a new window]   Figure 1 Relation between neutrophil O2–-generating capacity and NYHA functional class in patients with ischemic and nonischemic CHF. *p < 0.0001.

View larger version (15K): [in a new window]   Figure 2 (a) Mean plasma lipid-derived FR levels in patients with nonischemic CHF before and after short-term vitamin C (VC) therapy versus those subjects receiving placebo. *p < 0.05. (b) Mean plasma TBARS in patients with nonischemic CHF before and after short-term VC therapy versus those subjects receiving placebo. (c) Mean O2– generation by activated neutrophils in patients with nonischemic CHF before and after short-term VC therapy versus those subjects receiving placebo. Data are shown as the mean value ± SEM. Solid bar = baseline; open bar = after treatment.

View larger version (9K): [in a new window]   Figure 3 Relation between changes in FMD and lipid-derived FRs in patients with nonischemic CHF given intravenous vitamin C.

View larger version (14K): [in a new window]   Figure 4 (a) Mean plasma lipid-derived FR levels in patients with nonischemic CHF before and after long-term vitamin C (VC) therapy versus those subjects receiving placebo. *p < 0.05. (b) Mean plasma TBARS in patients with nonischemic CHF before and after long-term VC therapy versus those subjects receiving placebo. (c) Mean O2– generation by activated neutrophils in patients with nonischemic CHF before and after long-term VC therapy versus those subjects receiving placebo. Data are shown as the mean value ± SEM. *p < 0.05. Solid bar = baseline; open bar = after treatment.