Vascular repair after balloon overstretch injury in porcine model effects of intracoronary radiation
Yves Cottin, MD, PhD*,
Marc Kollum, MD*,
Rosanna Chan, PhD ,
Balram Bhargava, MD*,
Yoram Vodovotz, PhD* and
Ron Waksman, MD, FACC*
* Cardiovascular Research Institute, Washington Hospital Center, Washington, DC, USA
Department of Radiation Oncology, Washington Hospital Center, Washington, DC, USA
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Figure 1 Distribution of thrombus and dissection from pig arteries after balloon injury with and without radiation. Porcine coronary arteries were injured by balloon overstretch and subsequently treated with either 0 or 18 Gy of 90Y prescribed to 1.2 mm from the balloon center. Treated arteries were analyzed 14 days after treatment (*p < 0.05 Control vs. 18 Gy).
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Figure 2 Cross-section of (A) control artery and (B) irradiated artery 14 days after intervention. Similar dissection area in both arteries. (A) shows the dissection area filled with neointima and severe luminal stenosis. (B) shows mural thrombus with red and white blood cell, platelet and fibrin deposition and a wide open lumen; van-Giesson staining, magnification 7.5x.
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Figure 3 (A) Correlation between dissection area and intimal area in the two groups. (B) Correlation between dissection area and total thrombus area in the two groups. (C) Correlation between dissection area and mural thrombus area in the irradiated groups. Porcine coronary arteries were injured by balloon overstretch and subsequently treated with either 0 or 18 Gy of 90Y prescribed to 1.2 mm from the balloon center. Treated arteries were analyzed 14 days after treatment.
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