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Dichloroacetate improves postischemic function of hypertrophied rat hearts

Richard B. Wambolt, BSc^*, Gary D. Lopaschuk, PhD, Roger W. Brownsey, PhD and Michael F. Allard, BSc, MD^*

^* Department of Pathology and Laboratory Medicine, University of British Columbia, St. Paul’s Hospital, Vancouver, British Columbia, Canada
Cardiovascular Research Group, University of Alberta, Edmonton, Alberta, Canada
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

View larger version (18K): [in a new window]   Figure 1 Mechanical function of untreated control (open circles) and hypertrophied (open squares) hearts and DCA-treated control (solid circles) and hypertrophied hearts (solid squares) during preischemic perfusion and reperfusion after ischemia (n = 6 to 13 per group). Significant differences (p < 0.05) are indicated as *versus untreated preischemic control hearts; #versus untreated preischemic hypertrophied hearts; versus reperfused untreated control hearts; versus reperfused untreated hypertrophied hearts.

View larger version (32K): [in a new window]   Figure 2 Rates of glycolysis in untreated control (open bar) and hypertrophied (solid bar) hearts and DCA-treated control (hatched bar) and hypertrophied hearts (stippled bar) during preischemic perfusion (Before Ischemia) and reperfusion after ischemia (Reperfusion) (n = 6 to 13 per group). Significant differences (p < 0.05) are indicated as *versus untreated preischemic control hearts; #versus untreated preischemic hypertrophied hearts; versus reperfused untreated control hearts; versus reperfused untreated hypertrophied hearts.

View larger version (42K): [in a new window]   Figure 3 Rates of glucose oxidation in untreated control (open bar) and hypertrophied (solid bar) hearts and DCA-treated control (hatched bar) and hypertrophied hearts (stippled bar) during preischemic perfusion (Before Ischemia) and reperfusion after ischemia (Reperfusion) (n = 6 to 13 per group). Significant differences (p < 0.05) are indicated as *versus untreated preischemic control hearts; #versus untreated preischemic hypertrophied hearts; versus reperfused untreated control hearts; versus reperfused untreated hypertrophied hearts.

View larger version (31K): [in a new window]   Figure 4 Rates of H+ production from glucose metabolism in untreated control (open bar) and hypertrophied (solid bar) hearts and DCA-treated control (hatched bar) and hypertrophied (stippled bar) hearts during preischemic perfusion (Before Ischemia) and reperfusion after ischemia (Reperfusion) (n = 6 to 13 per group). Significant differences (p < 0.05) are indicated as *versus untreated preischemic control hearts; #versus untreated preischemic hypertrophied hearts; versus reperfused untreated control hearts; versus reperfused untreated hypertrophied hearts. H+ production arising from glucose metabolism was calculated by subtracting the rate of glucose oxidation from the rate of glycolysis and multiplying by 2 (9).