HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jenkins, P. C. Articles by O’Connor, G. T. Search for Related Content PubMed PubMed Citation Articles by Jenkins, P. C. Articles by O’Connor, G. T.

Survival analysis and risk factors for mortality in transplantation and staged surgery for hypoplastic left heart syndrome

Pamela C. Jenkins, MD, PhD^*, Michael F. Flanagan, MD, FACC^*, Kathy J. Jenkins, MD, MPH, James D. Sargent, MD^*, Charles E. Canter, MD, FACC, Richard E. Chinnock, MD, Robert N. Vincent, MD, FACC^||, Anna N. A. Tosteson, ScD^¶ and Gerald T. O’Connor, PhD, DSc, FACC^¶

^* Department of Pediatrics, Dartmouth Medical School, Hanover, New Hampshire, USA
Department of Cardiology, Children’s Hospital, Boston, Massachusetts, USA
Department of Cardiology, St. Louis Children’s Hospital, St. Louis, Missouri, USA
Department of Cardiology, Loma Linda University Children’s Hospital, Loma Linda, California, USA
^|| Department of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA
^¶ Departments of Medicine and Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA

View larger version (27K): [in a new window]   Figure 1 Distribution of 242 patients with HLHS who met entry criteria.

View larger version (12K): [in a new window]   Figure 2 Survival curves for transplantation and staged surgery. Unadjusted survival curves.

View larger version (18K): [in a new window]   Figure 3 The timing of mortality in each strategy. The difference in mortality is significant for preoperative, one-year and five-year mortality: *p < 0.001, p < 0.01.

View larger version (20K): [in a new window]   Figure 4 Comparison of one-year mortality rates by valvar atresia. Transplantation had a lower mortality for atresia of one or both left-sided valves than staged surgery does; differences are significant at the p < 0.05 level.

View larger version (25K): [in a new window]   Figure 5 Relative contribution of each risk factor to the explained one-year mortality risk. This pie graph shows that the increased mortality encountered with aortic and mitral atresia in staged surgery accounts for >50% of the explained mortality risk in patients with HLHS.