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Outcomes 15 years after valve replacement with a mechanical versus a bioprosthetic valve: final report of the Veterans Affairs randomized trial

Karl Hammermeister, MD, FACC^*, Gulshan K. Sethi, MD, FACC, William G. Henderson, PhD, Frederick L. Grover, MD, FACC^*, Charles Oprian, PhD and Shahbudin H. Rahimtoola, MB, FRCP, MACP, MACC

^* Denver VA Medical Center and University of Colorado Health Sciences Center, Denver, Colorado, USA
Tucson VA Medical Center and University of Arizona Health Sciences Center, Tucson, Arizona, USA
Hines VA Medical Center, Hines, Illinois, USA
LAC and USC Medical Center, University of Southern California, Los Angeles, California, USA

View larger version (27K): [in a new window]   Figure 1 Death from any cause (including operative mortality). AVR = aortic valve replacement; MVR = mitral valve replacement.

View larger version (29K): [in a new window]   Figure 2 Occurrence of one or more valve-related complications (bleeding, endocarditis, systemic embolism, nonthrombotic valve obstruction, valvular regurgitation or valve thrombosis). AVR = aortic valve replacement; MVR = mitral valve replacement.

View larger version (28K): [in a new window]   Figure 3 One or more clinically significant bleed(s). AVR = aortic valve replacement; MVR = mitral valve replacement.

View larger version (29K): [in a new window]   Figure 4 Primary valve failure (nonthrombotic valve obstruction or central valvular regurgitation). AVR = aortic valve replacement; MVR = mitral valve replacement.

View larger version (29K): [in a new window]   Figure 5 Reoperation for any reason on randomized valve. AVR = aortic valve replacement; MVR = mitral valve replacement.

View larger version (22K): [in a new window]   Figure 6 Primary valve failure among aortic valve replacement patients <65 and 65 years of age. AVR = aortic valve replacement; MVR = mitral valve replacement.