Relation of tissue Doppler derived myocardial velocities to myocardial structure and beta-adrenergic receptor density in humans
Kesavan Shan, MD*,
Roger J. Bick, PhD ,
Brian J. Poindexter, MSc,
Sarah Shimoni, MD*,
George V. Letsou, MD ,
Michael J. Reardon, MD,
Jimmy F. Howell, MD,
William A. Zoghbi, MD, FACC* and
Sherif F. Nagueh, MD, FACC*
* Department of Medicine, Section of Cardiology, Baylor College of Medicine, USA
Department of Surgery, Baylor College of Medicine, USA
Department of Pathology, University of Texas Medical School, Houston, Texas, USA
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Figure 1 (Top panel) Fluorescent labeling of beta-adrenoreceptors (green) and nuclei (blue with 4'6'-diamidino-2-phenylindole chloride, 0.1 g/ml). (A) Normal segment (B) Dysfunctional segment. (Middle panel) Mallory’s trichrome stain for interstitial fibrosis. (A) Normal segment; (B) Dysfunctional segment. (Lower panel) Tissue Doppler velocities. Am = late diastolic myocardial velocity; Em = early diastolic myocardial velocity; Sm = systolic myocardial velocity; from normal (A) and dysfunctional (B) segments. Notice the higher beta-adrenergic receptor density, the lower amount of interstitial fibrosis and the preserved Sm and Em velocities in the normal segment.
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Figure 2 (Upper panel) Relation of Em to beta-adrenoreceptor density. (Lower panel) Relation of Em to the percent of interstitial fibrosis. Em = early diastolic velocity.
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Figure 3 (Upper panel) Relation of Sm to beta-adrenoreceptor density. (Lower panel) Relation of Sm to the percent of interstitial fibrosis. Sm = myocardial systolic velocity.
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