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Left ventricular systolic dysfunction during exercise and dobutamine stress in patients with hypertrophic cardiomyopathy

^a Second Department of Internal Medicine, Kanazawa University, Kanazawa, Japan
^* Department of Nuclear Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan

View larger version (29K): [in a new window]   Figure 1 Diagrammatic representation of five-segment regional wall motion analysis in four standard two-dimensional echocardiographic views. AP = apical wall; AW = anterior wall; IVS = interventricular septum; LW = lateral wall; PW = posterior wall.

View larger version (19K): [in a new window]   Figure 2 Correlation between the change in ejection fraction during VEST and during DSE. Open circles = group I; closed circles = group II. DSE = dobutamine stress echocardiography; LVEF = change in left ventricular ejection fraction from baseline to peak stress; VEST = continuous ventricular function monitor.

View larger version (19K): [in a new window]   Figure 3 Left ventricular ejection fraction response during dobutamine stress echocardiography in group I (open circles) and group II (closed circles). Circles and bars indicate the mean value ± SD. Data were analyzed by two-way repeated measures analysis of variance (group effect p = 0.0046, dobutamine effect p = 0.0002, interaction p < 0.0001).

View larger version (32K): [in a new window]   Figure 4 Changes in regional wall motion during dobutamine stress echocardiography. The numbers inside the squares represent the number of myocardial segments. The numbers outside the squares represent the number of segments with changes in regional wall motion from baseline to low dose dobutamine infusion and from low dose to peak dose dobutamine infusion. Dotted arrows indicate worsening of wall motion during dobutamine stress echocardiography.