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High-dose intravenous isosorbide-dinitrate is safer and better than Bi-PAP ventilation combined with conventional treatment for severe pulmonary edema

Ahuva Sharon, MD^a, Isaac Shpirer, MD^b, Edo Kaluski, MD, FACC , Yaron Moshkovitz, MD, Olga Milovanov, MD^a , Roman Polak, MD^a, Alex Blatt, MD , Avi Simovitz, EMS^||, Ori Shaham, EMS^||, Zvi Faigenberg, MD^||, Michael Metzger, David Stav, MD^b, Robert Yogev, MD^a, Ahuva Golik, MD^a, Rikardo Krakover, MD, Zvi Vered, MD, FACC and Gad Cotter, MD

^a Department of Medicine, Assaf-Harofeh Medical Center, Zerifin, Israel
^b Department of Pulmonology, Assaf-Harofeh Medical Center, Zerifin, Israel
The Cardiology Institute, Assaf-Harofeh Medical Center, Zerifin, Israel
Clinical Pharmacology Research Unit, Assaf-Harofeh Medical Center, Zerifin, Israel
^|| Magen-David-Adom (EMS Service), Zefirin, Israel

View larger version (22K): [in a new window]   Figure 1 Recruitment algorithm of the study (six month period).

View larger version (12K): [in a new window]   Figure 2 Changes in oxygen saturation during study period comparing the high dose IV ISDN Group and the BiPAP group.