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Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease

Lawrence M. Title, MD^*, Peter M. Cummings, BA, MSc, Karen Giddens^*, Jacques J. Genest, Jr, MD and Bassam A. Nassar, MB, PhD, BCh

^* Division of Cardiology at the Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
Department of Pathology and Laboratory Medicine at the Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
Institut de Recherches Cliniques de Montréal, Montréal, Québec, Canada

View larger version (12K): [in a new window]   Figure 1 Mean (±SE) change in FMD after four months of therapy in the three treatment groups: placebo group (n = 25); folic acid only group (n = 25); and folic acid plus antioxidants group (n = 25) (p = 0.036 for overall comparison of the three groups). Compared with placebo, folic acid alone significantly improved FMD after four months (p = 0.04). In contrast, the improvement in the folic acid plus antioxidants group was not significantly different from that in the placebo group (p = 0.45) or the folic acid only group (p > 0.5).