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Increased expression of peripheral benzodiazepine receptors on leukocytes in silent myocardial ischemia

Antonino Mazzone, MD^*, Iolanda Mazzucchelli, BSc^*, Monia Vezzoli, MD^*, Elena Ottini, MD^*, Carla Auguadro, MD, Alessandra Serio, MD and Colomba Falcone, MD

^* Department of Internal Medicine and Nephrology, IRCCS, San Matteo Hospital, University of Pavia, Pavia, Italy
Department of Cardiology, IRCCS, San Matteo Hospital, University of Pavia, Pavia, Italy

View larger version (37K): [in a new window]   Figure 1 The fluorescence intensity of Bodipy Ro-1986 in a symptomatic patient and in an asymptomatic patient before and after incubation with a high concentration of the agonist Ro5-4864 without fluorescein. Specific staining was expressed as the mean channel fluorescence intensity.

View larger version (39K): [in a new window]   Figure 2 In patients with silent ischemia (A), the PBRs expression was significantly higher than that in symptomatic patients (P) in all types of leukocytes. L = lymphocytes; M = monocytes; N = neutrophils. #p < 0.005. ##p < 0.001.