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Hyperinsulinemia during oral glucose tolerance test is associated with increased neointimal tissue proliferation after coronary stent implantation in nondiabetic patients

A serial intravascular ultrasound study

^a Division of Cardiology, Kobe General Hospital, Minatojima Nakamachi, Kobe, Japan
^* Division of Cardiology, Department of Internal Medicine, Kawasaki Medical University, Kurashiki, Japan

View larger version (162K): [in a new window]   Figure 1 Representative planar intravascular ultrasound images of Palmaz-Schatz stent at follow-up are shown. Each is duplicated, and the duplicate is labeled. In patient without glucose intolerance (left), the stent area measured 6.4 mm2, and the lumen area measured 4.6 mm2. Thus, there was 1.8 mm2 of neointimal tissue proliferation and the neointimal index was 28%. In patient with impaired glucose tolerance (right), the stent area measured 6.3 mm2, and the lumen area measured 2.2 mm2. Thus, there was 4.1 mm2 of neointimal tissue proliferation and the neointimal index was 65%.

View larger version (30K): [in a new window]   Figure 2 Relation between insulin levels (top panel) and plasma glucose levels (bottom panel) and neointimal index.