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Randomized trial of low molecular weight heparin (enoxaparin) versus unfractionated heparin for unstable coronary artery disease^**

One-year results of the essence study

Shaun G. Goodman, MD, FACC^a, Marc Cohen, MD, FACC^*, Frederique Bigonzi, MD, Enrique P. Gurfinkel, MD, David R. Radley, MSc, Veronique Le Iouer, MS^d, Gregg J. Fromell, MD, Christine Demers, MD, Alexander G. G. Turpie, MD^||, Robert M. Califf, MD, FACC^¶, Keith A. A. Fox, MD^#, Anatoly Langer, MD, FACC for the Efficacy and Safety of Subcutaneous Enoxaparin in Non–Q Wave Coronary Events (ESSENCE) Study Group^**

^a Canadian Heart Research Center, Division of Cardiology, St. Michael’s Hospital, University of Toronto, Toronto, Canada
^* Division of Cardiology, Allegheny University Hospitals, Hahnemann Division, Philadelphia, Pennsylvania, USA
Rhone-Poulenc Rorer Corp., Antony, France
^d Rhone-Poulenc Rorer Corp., Collegeville, Pennsylvania, USA
Institute of Cardiology, Favaloro Foundation, Buenos Aires, Argentina
Hopital St. Sacrement, Quebec, Canada
^|| McMaster University, Hamilton, Canada
^¶ Duke University, Durham, North Carolina, USA
^# Royal Infirmary, Edinburgh, United Kingdom

View larger version (22K): [in a new window]   Figure 1 Trial profile.

View larger version (19K): [in a new window]   Figure 2 Kaplan-Meier plots of the time to a first event over a period of one year for the composite triple end point of death, MI or recurrent angina and for the composite double end point of death or MI.

View larger version (22K): [in a new window]   Figure 3 Kaplan-Meier plots of the time to a first diagnostic cardiac catheterization and the time to a first coronary revascularization over a period of one year.