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Exercise training restores ischemic preconditioning in the aging heart

^a Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche—Cattedra di Geriatria, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, Naples, Italy
^b Fondazione "Salvatore Maugeri"—IRCCS—Centro Medico di Telese Terme, Benevento, Italy
^c Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Napoli Federico II, Naples, Italy
^d Department of Medicine, University of California, San Diego, California, USA

View larger version (21K): [in a new window]   Figure 1 Bar graphs showing final recovery of percent DP (%) at 40 min of reperfusion in adult (open bars) and sedentary (solid bars) or trained (striped bars) senescent hearts subjected to ischemia for 20 min and reperfused for 40 min (standard ischemia-reperfusion insult, Control), treated with preconditioning transient ischemic stimulus for 2 min followed by 10 min of reperfusion and then a standard ischemia-reperfusion insult (PC) and treated with preconditioning transient ischemic stimulus for 2 min followed by 10 min of reperfusion and then a standard ischemia-reperfusion insult after pretreatment with reserpine (Res-PC). (*p < 0.05 vs. sedentary and trained senescent hearts; p < 0.01 vs. Control and Res-PC; p < 0.05 vs. sedentary senescent hearts; p < 0.05 vs. Control and Res-PC trained senescent hearts).