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J Am Coll Cardiol, 2000; 36:643-650
© 2000 by the American College of Cardiology Foundation
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Exercise training restores ischemic preconditioning in the aging heart

Pasquale Abete, MD, PhDa, Claudio Calabrese, MDa, Nicola Ferrara, MDa,b, Angelo Cioppa, MDa, Paolo Pisanelli, MDa, Francesco Cacciatore, MD, PhDa, Giancarlo Longobardi, MDb, Claudio Napoli, MD, FACAc,d and Franco Rengo, MDa,b

a Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche—Cattedra di Geriatria, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, Naples, Italy
b Fondazione "Salvatore Maugeri"—IRCCS—Centro Medico di Telese Terme, Benevento, Italy
c Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Napoli Federico II, Naples, Italy
d Department of Medicine, University of California, San Diego, California, USA



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  		Figure 1 Bar graphs showing final recovery of percent DP (%) at 40 min of reperfusion in adult (open bars) and sedentary (solid bars) or trained (striped bars) senescent hearts subjected to ischemia for 20 min and reperfused for 40 min (standard ischemia-reperfusion insult, Control), treated with preconditioning transient ischemic stimulus for 2 min followed by 10 min of reperfusion and then a standard ischemia-reperfusion insult (PC) and treated with preconditioning transient ischemic stimulus for 2 min followed by 10 min of reperfusion and then a standard ischemia-reperfusion insult after pretreatment with reserpine (Res-PC). (*p < 0.05 vs. sedentary and trained senescent hearts; {dagger}p < 0.01 vs. Control and Res-PC; {ddagger}p < 0.05 vs. sedentary senescent hearts; §p < 0.05 vs. Control and Res-PC trained senescent hearts).

 




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