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Responses to constant work rate bicycle ergometry exercise in primary pulmonary hypertension: the effect of inhaled nitric oxide

^a Division of Respiratory and Critical Care Physiology and Medicine, St. John’s Cardiovascular Research Center, Harbor-UCLA Medical Center, Torrance, California, USA
^b Division of Cardiology, St. John’s Cardiovascular Research Center, Harbor-UCLA Medical Center, Torrance, California, USA

View larger version (24K): [in a new window]   Figure 1 Data from a patient with PPH with illustration of the components of the single-exponential curves used to describe the exercise and recovery responses. In each case, the exponential function starts after a time delay. Exercise: O2 = c + A(1 – e-(t – td)/), where c is preexercise baseline O2; A is amplitude from baseline to asymptotic value; td is time delay; and is time constant. Recovery: O2 = c + Ae-(t – td)/, where c is end-recovery asymptotic O2; A is amplitude of response; td is time delay; and is time constant.

View larger version (21K): [in a new window]   Figure 2 Illustration of the calculation of O2 deficit and EPOC in a patient with PPH. Excess postexercise oxygen consumption (EPOC) was calculated for a recovery period of 10 min.

View larger version (15K): [in a new window]   Figure 3 Excess postexercise oxygen consumption (EPOC) plotted as a function of O2 deficit in PPH patients breathing air and breathing NO and in normals breathing air. The line of identity is shown by the dashed line. The combined line of regression is illustrated by the solid line. (EPOC = 0.87(O2 deficit) + 0.31, r = 0.84, p < 0.0001).