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Circadian rhythm and sudden death in heart failure

Results from prospective randomized amlodipine survival trial

Peter A. Carson, MD, FACC^*, Christopher M. O’Connor, MD, FACC, Alan B. Miller, MD, FACC, Susan Anderson, PhD, Robert Belkin, MD, FACC^||, Gerald W. Neuberg, MD, FACC^¶, John H. Wertheimer, MD, FACC^**, David Frid, MD, Anne Cropp and Milton Packer, MD, FACC^¶

^* VA Medical Center, Washington, DC, USA
Duke University Medical Center, Durham, North Carolina, USA
University of Florida, Jacksonville, Florida, USA
University of Wisconsin, Madison, Wisconsin, USA
^|| Valhalla, New York, New York, USA
^¶ Columbia University, New York, New York, USA
^** Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA
Ohio State University, Columbia, Ohio, USA
Pfizer Inc., Groton, Connecticut, USA

View larger version (16K): [in a new window]   Figure 1 All sudden deaths graphed by 4-h intervals. Analysis includes those with 4-h interval time of death with partial count included for each hour of the interval.

View larger version (17K): [in a new window]   Figure 2 Sudden death in the ischemic and nonischemic strata with time of death within 4-h intervals.

View larger version (18K): [in a new window]   Figure 3 All sudden deaths with time of death within 1-h intervals.

View larger version (17K): [in a new window]   Figure 4 All sudden deaths with a presenting identifiable rhythm. (A) Ventricular tachycardia or fibrillation; (B) other rhythms.