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Diffuse intimal thickening of coronary arteries in patients with coronary spastic angina

^a Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

View larger version (36K): [in a new window]   Figure 1 Schematic representation of intravascular ultrasound analyses at coronary cross-sectional image.

View larger version (148K): [in a new window]   Figure 2 Representative images of the left coronary angiogram and the intravascular ultrasound (IVUS) in a patient with coronary spastic angina. (Top right) Intracoronary injection of acetylcholine (100 µg) induced subtotal occlusion of the left anterior descending and left circumflex coronary artery. (Bottom left) After administration of isosorbide dinitrate, the coronary arteries were dilated and no fixed stenosis was noted. Intravascular ultrasound image exhibited a thickened I + M area and this lesion existed eccentrically (the position of the ultrasound transducer is noted by the black arrow on the angiogram after administration of isosorbide dinitrate).

View larger version (24K): [in a new window]   Figure 3 Correlation between percent I + M area versus percent changes from baseline in coronary lumen diameters in response to acetylcholine (10 µg).