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Atorvastatin but not L-arginine improves endothelial function in type I diabetes mellitus: a double-blind study

Michael J. Mullen, MRCP^*, David Wright, PhD, Ann E. Donald, AVT^*, Sara Thorne, MD, MRCP^*, Hyeyoung Thomson, BSc^* and John E. Deanfield, FRCP^*

^* Vascular Physiology Unit, Great Ormond Street Hospital for Children, London, UK
Department of Statistical Science, University College London, Gower Street, London, UK

View larger version (14K): [in a new window]   Figure 1 Study protocol. Subjects were randomized to either placebo, L-arginine (7 g twice daily), atorvastatin (40 mg/day) or combination therapy. Vascular function was assessed noninvasively at baseline and after six weeks of treatment.