This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Skyrme-Jones, R. A. P. Articles by Meredith, I. T. Search for Related Content PubMed PubMed Citation Articles by Skyrme-Jones, R. A. P. Articles by Meredith, I. T.

Vitamin E supplementation improves endothelial function in type I diabetes mellitus: a randomized, placebo-controlled study

R. Andrew P. Skyrme-Jones, BSc, MB, ChB^*,1, Richard C. O’Brien, MBBS, PhD, Karen L. Berry, BSc^* and Ian T. Meredith, MBBS, PhD^*

^* Centre for Heart and Chest Research, Monash Medical Centre and Monash University, Melbourne, Australia
Department of Medicine, Monash Medical Centre and Monash University, Melbourne, Australia

View larger version (22K): [in a new window]   Figure 1 a, Plasma VEC in placebo subgroup (striped bars at baseline; solid bar after treatment) and vitamin E–treated subgroup (open bar at baseline; solid bar after treatment). b, Low density lipoprotein VEC in placebo subgroup (striped bars at baseline; solid bar after treatment) and vitamin E–treated subgroup (open bar at baseline; solid bar after treatment).

View larger version (25K): [in a new window]   Figure 2 a, Flow-mediated dilation in placebo subgroup (striped bars at baseline; solid bar after treatment) and vitamin E–treated subgroup (open bar at baseline; solid bar after treatment). Flow-mediated dilation was not altered in the placebo group, but showed a significant increase after vitamin E therapy. b, Nitroglycerin-induced vasodilation. After vitamin E supplementation, there was a trend toward an improvement in the NTG response.

View larger version (19K): [in a new window]   Figure 3 a, Relation between the change () in FMD and the change in LDL VEC at follow-up in the cohort. As the LDL vitamin E increases, so does the magnitude of FMD (r = 0.42, p < 0.05). b, Relation between FMD and the change in lag time to oxidation of LDL at follow-up. Reduced oxidative susceptibility after vitamin E supplementation is associated with improved FMD (r = 0.64, p < 0.0001).

View larger version (17K): [in a new window]   Figure 4 Absolute forearm blood flow (a) and absolute forearm vascular resistance (b) during graded intra-arterial infusion of ACh before (open circles) and after (solid circles) therapy with vitamin E and before (open squares) and after (solid squares) placebo. Absolute forearm blood flow and vascular resistance were augmented after vitamin E therapy, but there was no change in the response in the placebo group (ANOVA, p < 0.05).