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Effect of carvedilol in comparison with metoprolol on myocardial collagen postinfarction

Shan Wei, PhD^*, Louis T. C. Chow, FRCPath and John E. Sanderson, MD, FRCP, FACC^*

^* Division of Cardiology, Department of Medicine and Therapeutics, Hong Kong SAR, China
Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China

View larger version (35K): [in a new window]   Figure 1 Effects of long-term treatment with carvedilol (Carv), metoprolol (Met) and captopril (Cap) on collagen volume fraction in the noninfarcted area of the left ventricle (top) and the right ventricle (bottom) post-MI compared with untreated rats with MI taking vehicle (V) and sham-operated rats. Values are mean ± SE. *p < 0.05 versus untreated rats with MI. Rat groups are as in text. Numbers of animals in each group are as in Table 1.

View larger version (31K): [in a new window]   Figure 2 Effects of long-term treatment with carvedilol (Carv), metoprolol (Met) and captopril (Cap) on hydroxyproline contents in the interventricular septum (top) and the right ventricle (bottom) post-MI compared with untreated rats with MI taking vehicle (V) and sham-operated rats. Values are mean ± SE. *p < 0.05 versus untreated rats with MI. Rat groups are as in text. Numbers of animals in each group are as in Table 1.