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Effects of insulin-glucose infusion on left ventricular function at rest and during dynamic exercise in healthy subjects and noninsulin dependent diabetic patients

A radionuclide ventriculographic study

Ferdinando Carlo Sasso, MD, PhD^*, Ornella Carbonara, MD^*, Domenico Cozzolino, MD^*, Pierfrancesco Rambaldi, MD, Luigi Mansi, MD, Daniele Torella, MD, Sandro Gentile, MD^*, Salvatore Turco, MD, Roberto Torella, MD^* and Teresa Salvatore, MD^*

^* Institute of Internal Medicine, Naples, Italy
Institute of Nuclear Medicine, Faculty of Medicine, 2nd University of Naples, University "Federico II" of Naples, Naples, Italy, Institute of Internal Medicine
Institute of Cardiology, University "Federico II" of Naples, Naples, Italy, Institute of Internal Medicine
Department of Clinical and Experimental Medicine, University "Federico II" of Naples, Naples, Italy

View larger version (17K): [in a new window]   Figure 1 Insulin and glucose plasma levels during saline infusion (test A). *p < 0.001.

View larger version (18K): [in a new window]   Figure 2 Insulin and glucose plasma levels during insulin-glucose infusion (test B). p < 0.05; p < 0.01; *p < 0.001.

View larger version (13K): [in a new window]   Figure 3 Relation between LVEF and ISI both at rest (top) and during exercise (bottom) in diabetic patients.