Provocation of neurocardiogenic syncope by clomipramine administration during the head-up tilt test in vasovagal syndrome
George N. Theodorakis, MD*,
Manolis Markianos, MD ,
Elias Zarvalis, MD*,
Efthimios G. Livanis, MD*,
Panagiota Flevari, MD* and
Dimitrios Th Kremastinos, MD*
* Onassis Cardiac Surgery Center, Second Department of Cardiology, Eginition Hospital, Athens University Medical School, Athens, Greece
Laboratory of Neurochemistry, Eginition Hospital, Athens University Medical School, Athens, Greece
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Figure 1 Results of B-HUT and Clom-HUT in the 55 subjects in each group. Twenty-five subjects in the patient group had a positive response during both B-HUT and Clom-HUT. Seven subjects in the patient group had a negative response during both B-HUT and Clom-HUT. Nineteen subjects in the patient group with a negative B-HUT response had a subsequent positive Clom-HUT response. Four subjects in the patient group with positive B-HUT had negative Clom-HUT response.
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Figure 2 Plasma levels (mean ± SE) of prolactin (PRL) and cortisol (CORT) at baseline and at 5, 10 and 20 min during Clom-HUT. Line with solid circles = patient group with a positive Clom-HUT response; line with open circles = patient group with a negative Clom-HUT response; line with solid triangles = control group with a negative Clom-HUT response. Analysis of variance with repeated measures was applied for statistical analysis. Planned comparisons: *Significant increases as compared with both other groups. #Significant increases as compared with the control group only.
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