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Enhanced secretion of cardiac hepatocyte growth factor from an infarct region is associated with less severe ventricular enlargement and improved cardiac function

^a Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan

View larger version (19K): [in a new window]   Figure 1 Correlations between the MI/non-MI ratio for hepatocyte growth factor (HGF) and the left ventricular end-diastolic volume index (LVEDVI: top panel) and ejection fraction (LVEF: bottom panel) in 40 patients with reperfusion therapy. The MI/non-MI ratio for HGF is a relative index of infarct-related HGF secretion, and was obtained as the ratio of the HGF level in the infarcted region (MI) to that in the noninfarcted region (non-MI).

View larger version (19K): [in a new window]   Figure 2 Correlations between the MI/non-MI ratio for brain natriuretic peptide (BNP) and the LVEDVI (top panel) and LVEF (bottom panel) in the same patient group as that shown in Figure 1.

View larger version (23K): [in a new window]   Figure 3 Correlations between the MI/non-MI ratio for HGF and LVEDVI (top panel) and LVEF (bottom panel). Changes in LVEDVI (LVEDVI) and LVEF (LVEF) were obtained by subtracting the respective values in the acute phase from the corresponding values in the chronic phase in 30 patients.

View larger version (14K): [in a new window]   Figure 4 Scattergraph showing comparison of the MI/non-MI ratios for HGF (top panel) and those for BNP (bottom panel) between patients administered (n = 40: REP) and those not administered reperfusion therapy in the acute phase (n = 10: NO REP).