This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Takehana, K. Articles by Glover, D. K. Search for Related Content PubMed PubMed Citation Articles by Takehana, K. Articles by Glover, D. K.

Response to incremental doses of dobutamine early after reperfusion is predictive of the degree of myocardial salvage in dogs with experimental acute myocardial infarction

^a Experimental Cardiology Laboratory, Cardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA

View larger version (12K): [in a new window]   Figure 1 Experimental protocol. LAD = left anterior descending coronary artery; mic = radiolabeled microspheres.

View larger version (27K): [in a new window]   Figure 2 Bar graph comparing mean risk area as a percent of left ventricle (%LV) and infarct size as a percent of risk area (%RA) between the two groups. *p < 0.01 vs. group 1.

View larger version (30K): [in a new window]   Figure 3 Comparison of myocardial blood flow in the left anterior descending coronary artery zone at the 30 µg·kg–1·min–1 dobutamine infusion. Note that endocardial, midwall and transmural blood flows in dogs with larger infarct size (group 2) were significantly lower than values in dogs with a smaller infarct size (group 1). Endocardial flow in group 2 failed to increase from baseline at peak dobutamine infusion. *p < 0.05 vs. group 1; p < 0.01 vs. group 1.

View larger version (24K): [in a new window]   Figure 4 Mean regional percent left ventricular wall thickening in dogs with smaller infarct size (group 1) (A) and with larger infarct size (group 2) (B). There was a significant difference in wall thickening between the LAD and normal LCx zones in both groups (p < 0.01, respectively). Thickening in the LCx zone (dashed lines) was stable before dobutamine infusion and increased during dobutamine infusion in both groups. In the LAD zone (solid lines), thickening was absent in both groups after reperfusion. Note that after graded dobutamine infusion, thickening in the LAD zone markedly increased in group 1 dogs and was not significantly different from normal LCx zone thickening at 20 and 30 µg·kg–1·min–1 dobutamine infusion. In contrast, group 2 dogs showed a significant attenuation of inotropic reserve in the LAD zone. Base = baseline; Full = full reperfusion; LAD = left anterior descending coronary artery; LCx = left circumflex coronary artery; Occ = occlusion; Part = partial reperfusion; Sten = stenosis; *p < 0.05 vs. LCx; p < 0.01 vs. LCx.

View larger version (20K): [in a new window]   Figure 5 Scatterplots of the correlations between infarct area (% risk area) and increase in thickening (% baseline) during dobutamine infusion. Significant inverse correlations were observed at 10, 20 and 30 µg·kg–1·min–1 dobutamine infusion, whereas there was no significant correlation during 5 µg·kg–1·min–1 dobutamine infusion. Regression lines are superimposed on the scatterplots.