Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina
Possible role of reactive oxygen species
Osamu Hirashima, MDa,
Hiroaki Kawano, MDa,
Takeshi Motoyama, MDa,
Nobutaka Hirai, MDa,
Masamichi Ohgushi, MDa,
Kiyotaka Kugiyama, MDa,
Hisao Ogawa, MDa and
Hirofumi Yasue, MDa
a Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
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Figure 1 Schematic representation of the experimental protocol. RH = analysis of reactive hyperemia; SSPG = steady-state plasma glucose.
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Figure 2 Effect of vitamin C on flow-mediated dilation in patients with coronary spastic angina and in control subjects. See text for details. Data are expressed as mean value ± SE. **Significant effect of vitamin C infusion on the CSA group compared with the control group, p < 0.001 by ANOVA. CSA = coronary spastic angina.
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Figure 3 Effect of vitamin C on steady-state plasma glucose in patients with coronary spastic angina and in control subjects. See text for details. Data are expressed as mean value ± SE. *Significant effect of vitamin C infusion on the CSA group compared with the control group, p < 0.05 by ANOVA. CSA = coronary spastic angina; SSPG = steady-state plasma glucose.
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Figure 4 Correlation between: (A) plasma vitamin C concentration and flow-mediated dilation, and that between (B) vitamin C concentration and steady-state plasma glucose before vitamin C infusion. SSPG = steady-state plasma glucose.
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Figure 5 Correlation between flow-mediated dilation and steady-state plasma glucose before vitamin C infusion. SSPG = steady-state plasma glucose.
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