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The shift in the myocardial adenine nucleotide translocator isoform expression pattern is associated with an enteroviral infection in the absence of an active T-cell dependent immune response in human inflammatory heart disease

^a Department of Cardiology, Benjamin Franklin Hospital, Free University Berlin, Berlin, Germany

View larger version (18K): [in a new window]   Figure 1 (A) The ANT isoform transcription pattern of patients with ICM (n = 22) and csIHD (n = 53) is described by its ANT1/(ANT2 + ANT3) mRNA ratio. Ischemic cardiomyopathy patients were found to have an identical ANT isoform profile with healthy people (13). Thus, the range of normal ANT isoform distribution was defined as the mean ± 3 SD of the ICM patient’s ratio and was marked by broken lines. The average percentage of each ANT isoform found in the myocardium of patients with csIHD that have an ANT1/ANT2 + ANT3 mRNA ratio outside the normal range (n = 21; solid bars) are shown in comparison with ICM patients (n = 22; open bars) in graph (B). Data are shown as means ± SEM. ANT = adenine nucleotide translocator; csIHD = clinically suspected inflammatory heart disease; ICM = ischemic cardiomyopathy.

View larger version (22K): [in a new window]   Figure 2 The ANT isoform distribution, described by the ANT1/ANT2 + ANT3) mRNA ratio, is shown for patients with ICM (n = 22) and patients with csIHD whose biopsies were free from enteroviral genome (virus-negative, n = 26) or infiltrated with enteroviral RNA (virus-positive, n ± 27). Broken lines mark the range of normal ANT isoform distribution. Data are shown as means ± SEM. ANT = adenine nucleotide translocator; csIHD = clinically suspected inflammatory heart disease; ICM = ischemic cardiomyopathy.

View larger version (13K): [in a new window]   Figure 3 The amount of CD3-positive T-cells infiltrating the endomyocardial biopsies from patients with csIHD with a normal (n = 32) or an altered ANTitp (n = 21). According to Kühl et al. (16), the normal range of intramyocardial T-cell infiltration was defined to be <7 cell/mm2. An excess of this limit, which is marked by the broken line in the graph, shows a pathological infiltration with T-cells. aANTitp = altered adenine nucleotide translocator isoform transcription pattern; csIHD = clinically suspected inflammatory heart disease; nANTitp = normal adenine nucleotide translocator isoform transcription pattern.

View larger version (12K): [in a new window]   Figure 4 The amount of CD3-specific cells infiltrating the heart tissue of virus-positive patients with csIHD shown to have a normal (n = 12) or an altered ANTitp (n = 15). According to Kühl et al. (16) the normal range of intramyocardial T-cell infiltration was defined to be <7 cell/mm2. aANTitp = altered adenine nucleotide translocator isoform transcription pattern; csIHD = clinically suspected inflammatory heart disease; nANTitp = normal adenine nucleotide translocator isoform transcription pattern.