Acute hemodynamic and neurohumoral effects of selective ETA receptor blockade in patients with congestive heart failure
Lukas E. Spieker, MDa,
Veselin Mitrovic, MD*,
Georg Noll, MD, FESCa,
Richard Pacher, MD ,
Matthias R. Schulze, MD ,
J.örg Muntwyler, MD, MPHa,
Christoph Schalcher, MDa,
Wolfgang Kiowski, MD, FACC, FESCa,
Thomas F. Lüscher, MD, FACC, FRCP, FESCa on behalf of the ET 003 Investigators
a Division of Cardiology, University Hospital, Zürich, Switzerland
* Kerckhoff Clinic, Bad Nauheim, Germany
Allgemeines Krankenhaus, Wien, Austria
Herz-und Kreislaufzentrum, Cardiology, Dresden, Germany

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Figure 1 Correlations between baseline endothelin (ET)-1 plasma levels and hemodynamic parameters in patients with chronic heart failure (n = 91). Mean pulmonary artery (MPAP, mm Hg; top) and pulmonary capillary wedge pressure (PCWP, mm Hg; middle) correlated positively with ET-1 plasma levels, while cardiac index (ml·min1·m2; bottom) was inversely associated with ET-1 levels.
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Figure 2 Changes of cardiac index and systemic vascular resistance 4 h after administration of different dosages of LU135252, a selective ETA receptor antagonist. *p < 0.05; **p 0.0002.
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Figure 3 Changes of endothelin-1 plasma levels after administration of various dosages of the selective ETA receptor antagonist LU135252. There was a dose-dependent increase in plasma ET-1 levels. *p < 0.003 vs. baseline.
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