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Inhibitory effects of low-density lipoproteins from men with type II diabetes on endothelium-dependent relaxation

Karen L. McNeill^*, Luigi Fontana, MD^*, David L. Russell-Jones, FRCP, Iris Rajman, PhD^*, James M. Ritter, FRCP^* and Philip J. Chowienczyk, FRCP^*

^* Department of Clinical Pharmacology, Centre for Cardiovascular Biology and Medicine, King’s College, London, United Kingdom
Department of Endocrinology and Diabetes, King’s College, London, United Kingdom

View larger version (14K): [in a new window]   Figure 1 Forearm blood flow during brachial artery infusion of acetylcholine (7.5, 15 and 30 µg/min) and nitroprusside (1, 3 and 10 µg/min) in healthy control men (n = 10, open squares) and men with type II diabetes (n = 10, closed squares). p < 0.01 for the comparison of blood flow responses to acetylcholine in men with type II diabetes compared with those in control subjects by ANOVA for repeated measures.

View larger version (18K): [in a new window]   Figure 2 Bioassay system to examine effects of n-LDL isolated from men with type II diabetes (n = 10, closed squares) and control subjects (n = 10, open squares) on endothelium-dependent relaxation to acetylcholine (ACh) in rabbit aortic rings preconstricted with noradrenaline. Relaxation in absence of n-LDL is shown in open circles. p value refers to comparison of inhibitory effects of n-LDL from men with type II diabetes with those of n-LDL from control subjects by ANOVA for repeated measures.

View larger version (32K): [in a new window]   Figure 3 Inhibitory effects of n-LDL isolated from control men (n = 10, open bars) and men with type II diabetes (n = 10, shaded bars) on relaxation of rabbit rings to acetylcholine. Percent inhibition refers to the difference between the sum of relaxations to all doses to acetylcholine in the absence and presence of n-LDL. p < 0.01 for the difference between effects of n-LDL from controls and diabetics.

View larger version (14K): [in a new window]   Figure 4 Effects of n-LDL isolated from men with type II diabetes (n = 10, closed squares) and control subjects (n = 10, open squares) on endothelium-independent relaxation to sodium nitroprusside in rabbit aortic rings preconstricted with noradrenaline. Relaxation in absence of n-LDL is shown in open circles.