Relationship between corrected TIMI frame counts at three weeks and late survival after myocardial infarction
John K. French, MB, PhDa,
Thomas A. Hyde, MBa,
Ivan T. Straznicky, MBa,
Jacqueline Andrews, MBa,
Mayanna Lund, MBa,
David J. Amos, MBa,
Andrew Zambanini, MBa,
Christopher J. Ellis, MBa,
Bruce J. Webber, DSRa,
Stephanie C. McLaughlin, PhDa,
Ralph M. L. Whitlock, MBa,
Samuel O. M. Manda, PhDa,
Hitesh Patel, MBa and
Harvey D. White, MB, DSc, FACCa
a Cardiology Department, Green Lane Hospital, Auckland, New Zealand
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Figure 1 Late actuarial outcome after myocardial infarction.
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Figure 2 Infarct-related artery flow in patients who underwent angiography at three weeks without imputation for early death. (A) Comparison of CTFCs and TIMI flow grades. (B) Influence of CTFC on late survival. The log rank comparisons (four-way) at one, five and 10 years were p = 0.06, p = 0.002 and p = 0.26, respectively. (C) Influence of TIMI flow grades on late survival. The log rank comparisons (three-way) at one, five and 10 years were p = 0.03, p = 0.0003 and p = 0.14, respectively. The log rank comparisons (two-way) between TIMI 3 and TIMI 0 to 1 and between TIMI 3 and TIMI 0 to 2 at one, five and 10 years were p = 0.009, p = 0.0001 and p = 0.049; and p = 0.025, p = 0.004 and p = 0.49, respectively. The log rank comparisons between TIMI 2 and TIMI 0 to 1 at one, five and 10 years were p = 0.25, p = 0.047 and p = 0.25, respectively. The log rank comparisons between TIMI 0 to 1 and TIMI 2 to 3 at one, five, and 10 years were p = 0.012, p = 0.0001 and p = 0.049, respectively. There were no significant differences in survival between patients with TIMI 2 and TIMI 3 flow. The results were similar when only thrombolytic-treated patients were analyzed (data not shown). CTFC = corrected TIMI frame count; TIMI = Thrombolysis in Myocardial Infarction.
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Figure 3 Influence of the CTFC on cardiac death. (A) At one year. (B) At five years. (C) At 10 years. The cumulative frequency is the percentage of patients with a CTFC not exceeding the X-value. CTFC = corrected TIMI frame count; TIMI = Thrombolysis in Myocardial Infarction.
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