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Distinct hemodynamic profiles in patients with vasovagal syncope: a heterogeneous population

Win-Kuang Shen, MD, FACC^*, Phillip A. Low, MD, Robert F. Rea, MD, FACC^*, Christine M. Lohse, BS, David O. Hodge, MS and Stephen C. Hammill, MD, FACC^*

^* Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
Peripheral Neuropathy Research Laboratory, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
Section of Biostatistics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA

View larger version (18K): [in a new window]   Figure 1 Percent of change of cardiomotor and vasomotor response to tilt. (A) Percentage change of heart rate, stroke volume and cardiac output from baseline supine to tilt position (70°) in the three groups of subjects: controls, tilt-positive patients and isoproterenol-positive patients. (B) Percentage change in systolic, diastolic and mean blood pressure (BP) and total peripheral resistance from supine to tilt position. *p < 0.05; ***p < 0.001.

View larger version (21K): [in a new window]   Figure 2 Cardiomotor function and response to isoproterenol between control subjects and isoproterenol-positive patients. (A) Percentage change in heart rate, stroke volume and cardiac output during isoproterenol infusion (0.05 µg/kg per min) in the supine position compared with baseline supine position. (B) Percentage change in heart rate, stroke volume and cardiac output during isoproterenol infusion from supine to tilt position.

View larger version (17K): [in a new window]   Figure 3 Vasomotor function in response to isoproterenol. (A) Percentage change in systolic, diastolic and mean blood pressure (BP) and total peripheral resistance during isoproterenol infusion in supine position compared with baseline supine position. (B) Percentage change in systolic, diastolic and mean blood pressure and total peripheral resistance during isoproterenol infusion from supine to tilt position. **p < 0.01; ***p < 0.001.