Inhibition of neointima formation by tranilast in pig coronary arteries after balloon angioplasty and stent implantation
Sugao Ishiwata, MD, FACC*,
Stefan Verheye, MD*,
Keith A. Robinson, PhD, FACC ,
Mahomed Y. Salame, MRCP*,
Hector de Leon, MD, PhD*,
Spencer B. King, III, MD, FACC* and
Nicolas A. F. Chronos, MD, FACC
* Andreas Gruentzig Cardiovascular Center, Department of Medicine (Cardiology), Emory University School of Medicine, Atlanta, Georgia, USA
Atlanta Cardiovascular Research Institute, Atlanta, Georgia, USA
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Figure 1 Light microscopy of VVG-stained sections of pig coronary arteries harvested four weeks after overstretch balloon angioplasty. Top panels are from control; bottom panels from tranilast-treated animal. Left panels are 40x instrument magnification; right panels 200x. Note decreased neointima formation in artery of tranilast-treated pig despite balloon injury similar to control. L = lumen; M = tunica media; A = tunica adventitia; N = neointima.
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Figure 2 Light microscopy of H&E-stained sections of pig coronary arteries harvested four weeks after stenting. Top panels are from control; bottom panels from tranilast-treated animal. Left panels are 20x instrument magnification; right panels 200x. Note similar neointima formation in artery of tranilast-treated pig despite stent injury greater than control (arrows in panel 2c). L = lumen; M = tunica media; A = tunica adventitia; N = neointima.
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