Comparative effects of pretreatment with captopril and losartan on cardiovascular protection in a rat model of ischemia-reperfusion
Bo-qing Zhu, MD, FACCa,
Yi-ping Sun, MDa,
Richard E. Sievers, BSa,
Amanda E. M. Browne, BSa,
Satyavardhan Pulukurthy, MDa,
Krishnankutty Sudhir, MD, PhD, FACCa,
Randall J. Lee, MD, PhD, FACCa,
Tony M. Chou, MD, FACCa,
Kanu Chatterjee, MD, FACCa and
William W. Parmley, MD, MACCa
a Division of Cardiology, Department of Medicine, University of California at San Francisco, San Francisco, California, USA
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Figure 1 A, Heart rate (beats/min) in the three groups of rats during 17 min of ischemia and 120 min of reperfusion. B, Systolic blood pressure; C, diastolic blood pressure; and D, the product of heart rate and systolic pressure during the same period. N = normal control group; C = captopril group; and L = losartan group. There were no significant differences in hemodynamic data between the three groups at any time point.
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Figure 2 The VF threshold before occlusion and after reperfusion in the three groups of rats. The VF threshold in groups L and C was statistically greater than that in group N, both before occlusion and after reperfusion. However, groups L and C were not statistically different (p = 0.861 and 0.238).
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Figure 3 Average episodes of VT and VF per rat during ischemia and reperfusion in the three groups of rats. The episodes in groups L and C were statistically less than those in group N. However, groups L and C were not statistically different (p = 0.545).
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Figure 4 Maximal endothelium-dependent vasorelaxation (Max-Relax) and slope induced by A23187 in the three groups of rats. The maximal relaxation and slope in group C were statistically greater than those in group N. However, group L was not statistically different from group N (p = 0.223) or group C (p = 0.337). Solid bars = Max-Relax; striped bars = slope.
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