This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Benetos, A. Articles by Guize, L. Search for Related Content PubMed PubMed Citation Articles by Benetos, A. Articles by Guize, L.

A decrease in diastolic blood pressure combined with an increase in systolic blood pressure is associated with a higher cardiovascular mortality in men

Athanase Benetos, MD, PhD^* , Mahmoud Zureik, MD, PhD, Jeff Morcet, BSc^*, Frédérique Thomas, PhD^*, Kathryn Bean, MA, MPH^*, Michel Safar, MD, Pierre Ducimetière, PhD and Louis Guize, MD^*

^* Centre d’Investigations Préventives et Cliniques (IPC), Paris, France
INSERM U337, Paris, France
INSERM U258, Villejuif, France

View larger version (23K): [in a new window]   Figure 1 Survival probability curves for cardiovascular mortality in different subgroups of subjects according to the changes in systolic and diastolic blood pressure, in the IPC Study (upper panel) and in the Paris Prospective Study I (lower panel). Reference group (RG; SysDia) included men whose systolic blood pressure and diastolic blood pressure did not change over time. The SysDia group included men whose systolic blood pressure increased and diastolic blood pressure decreased. Other Sys included those whose systolic blood pressure increased, whereas diastolic blood pressure did not change or else increased (groups SysDia and SysDia). Other Dia included those whose diastolic blood pressure decreased, whereas systolic blood pressure did not change or else decreased (groups SysDia and SysDia). In both cohorts the SysDia group showed higher cardiovascular mortality versus the RG (p < 0.05 in both cohorts). Other Dia groups showed similar cardiovascular mortality versus the RG, whereas other Sys groups presented intermediate cardiovascular mortality rates.