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Platelets and restenosis

^a Division of Interventional Cardiology, Montreal Heart Institute, Montreal, Canada

View larger version (24K): [in a new window]   Figure 1 Schematic representation of platelet-derived growth factors involved in neointimal proliferation after vascular injury. TxA2 = thromboxane A2; vWF = von Willebrand factor.

View larger version (19K): [in a new window]   Figure 2 Brief representation of possible mode of action of PDGF on SMC leading to restenosis. Numbers in parentheses indicate sites of action of various anti-PDGF drugs, as listed in Table 1. (Note: because this is only a schematic representation, it is not possible to show the site of action of all the drugs listed in Table 1.) 1,2-DG = 1,2-diacylglycerol; IP3 = inositol triphosphate; PKC = protein kinase C; PTK = protein tyrosine kinase.