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Three minute, but not one minute, ischemia and nicorandil have a preconditioning effect in patients with coronary artery disease

Tetsuo Matsubara, MD^* , Shinya Minatoguchi, MD, Hitoshi Matsuo, MD^* , Kenji Hayakawa, MD^* , Tomonori Segawa, MD^* , Yukihiko Matsuno, MD^* , Sachiro Watanabe, MD^* , Masazumi Arai, MD^*, Yoshihiro Uno, MD, Masanori Kawasaki, MD^* , Toshiyuki Noda, MD, Genzou Takemura, MD, Kazuhiko Nishigaki, MD and Hisayoshi Fujiwara, MD

^* Department of Cardiology, Gifu Prefectural Hospital, Gifu, Japan
Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan

View larger version (34K): [in a new window]   Figure 1 Study protocol. decrease: ECG (body surface 12 lead electrocardiogram); increase: CAG = coronary angiogram.

View larger version (36K): [in a new window]   Figure 2 Time course changes in hemodynamic parameters recorded at intervals of 1 min from the control to the end of final inflation. Upper panel: SBP significantly decreased 120 s after the administration of nicorandil or ISDN. Middle panel: DBP significantly decreased 120 s after the administration of nicorandil and significantly decreased only immediately after the administration of ISDN. Lower panel: HR did not alter throughout the experiment in all the groups. DBP = diastolic blood pressure; HR = heart rate; ISDN = isosorbide dinitrate; SBP = systolic blood pressure.

View larger version (57K): [in a new window]   Figure 3 Comparison of deltaST max and sigmaST during the second inflation among control (first inflation of the PC60 and PC180 groups), PC60, PC180, NC and ISDN groups. Significant decreases in ST elevation (deltaST max and sigmaST) in the PC180 group at every time point, and in the NC group at the 30 s and 60 s points after inflation, were observed.