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Endothelial vasodilator function is related to low-density lipoprotein particle size and low-density lipoprotein vitamin E content in type 1 diabetes

R. Andrew P. Skyrme-Jones, BSc, MB, ChB^*, Richard C. O’Brien, PhD, Ming Luo, PhD and Ian T. Meredith, MBBS, PhD, FACC^*

^* Centre for Heart and Chest Research, Monash Medical Centre and Monash University, Melbourne, Australia
Department of Medicine, Monash Medical Centre and Monash University, Melbourne, Australia

View larger version (15K): [in a new window]   Figure 1 Endothelium-dependent flow-mediated dilation (A) in diabetic (black bar) and control (white bar) subjects. FMD was significantly reduced in DM compared with control subjects (3.6 ± 0.6% vs. 7.1 ± 0.5%). Endothelium-independent GTN-induced vasodilation (B) was also reduced in DM compared with controls (15.4 ± 1.1% vs. 18.5 ± 0.8%), albeit to a lesser extent than FMD.

View larger version (23K): [in a new window]   Figure 2 Relationship between flow-mediated dilation in diabetic (filled circles) and control (open circles) subjects with LDLPS. There was a significant correlation between FMD and LDLPS in the study cohort (A) and the diabetic group alone (B).

View larger version (23K): [in a new window]   Figure 3 Relationship between flow-mediated dilation in diabetic (filled circles) and control (open circles) subjects with LDLVE. There was a significant correlation between FMD and LDLVE in the study cohort (A) and the diabetic group alone (B).

View larger version (18K): [in a new window]   Figure 4 Absolute increase in forearm blood flow (A) and absolute reduction in forearm vascular resistance (B) in diabetic subjects (filled circles) and control subjects (open circles) during graded intraarterial infusion of acetylcholine (ACh). The changes in forearm blood flow and vascular resistance were attenuated in the diabetic group compared with the control group (p < 0.05).

View larger version (32K): [in a new window]   Figure 5 (A and B) The relationship between the absolute change in forearm vascular resistance (FVR) at peak dose of acetylcholine (ACh) and LDLPS (A) and LDLVE (B) in diabetic (filled circles) and control subjects (open circles). (C and D) The relationship between the slope of the FVR ACh dose-response curve and LDLPS (C) and LDLVE (D).