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Effects of vitamin E on chronic and acute endothelial dysfunction in smokers

Thomas Neunteufl, MD^a, Ute Priglinger, MD^a, Sandra Heher, MD^a, Manfred Zehetgruber, MD^a, Gabor Söregi, MD^*, Stephan Lehr, Kurt Huber, MD^a, Gerald Maurer, MD, FACC^a, Franz Weidinger, MD and Karam Kostner, MD^a

^a Department of Cardiology, University of Vienna, Vienna, Austria
^* Department of Clinical Chemistry, University of Vienna, Vienna, Austria
Institute for Medical Statistics, University of Vienna, Vienna, Austria
Department of Cardiology, University of Innsbruck, Innsbruck, Austria

View larger version (14K): [in a new window]   Figure 1 Bar graph showing FMD values of subjects receiving placebo and of subjects receiving vitamin E (600 IU/day) at baseline, after therapy for four weeks and after heavy smoking at the end of the treatment period. Time factor p value = 0.0065. Group factor p value = 0.5834. Interaction of the time factor and the grouping factor: p = 0.0318. FMD = flow-mediated vasodilation. Open square = placebo; closed square = Vitamin E.

View larger version (16K): [in a new window]   Figure 2 FMD values before and after heavy smoking at the end of the treatment period for subjects receiving placebo as well as for subjects receiving vitamin E (600 IU/day). P values for the time factor = 0.0001; p value for the group factor = 0.0017. FMD = flow-mediated vasodilation.

View larger version (9K): [in a new window]   Figure 3 Transient impairment of FMD (delta FMD) after heavy smoking vs. improvement of the antioxidant status (delta TBARS) under vitamin E supplementation for four weeks. FMD = flow-mediated dilation; TBARS = thiobarbituric acid-reactive substances.