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Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia

^a Cardiovascular Sciences Research Group, University of Wales College of Medicine, Cardiff, United Kingdom

View larger version (14K): [in a new window]   Figure 1 The effect of four months of treatment with placebo and omega-3 fatty acids on the following. A, Brachial artery blood flow (expressed as percent change from baseline) at: peak flow immediately after wrist cuff deflated, 1 min after cuff deflated and 3 min after 400 µg sublingual GTN. There were no significant differences between groups. B, Flow-mediated dilation expressed as absolute change (mm) from baseline diameter. There is a significant improvement within the omega-3 fatty acids group posttreatment (*p < 0.05) and when compared with placebo posttreatment (**p < 0.05). C, Glyceryl trinitrate-mediated dilation expressed as absolute change (mm) from baseline diameter. There were no significant differences between groups. Data are presented as mean ± SEM. Solid bars = posttreatment; Open bars = pretreatment.